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I felt bonded to him my whole heart beats and skips

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cheap jerseys nba cheap nba Jerseys free shipping I mean we all know those line i have used them and we all have the next words are always «I think we should take a break» which mean i want out of this relationship. I wish he told me all those things before he asked me to marry him i would totally move on with my life but now, it turn out that we were already engaged and for six months at that. I felt bonded to him my whole heart beats and skips just for him for the record his name is Sean. cheap nba Jerseys free shipping

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wholesale nba jerseys cheap nba Jerseys from china Here, we propose plasma neurofilament light chain (NfL) levels as a biomarker of neuroaxonal damage in patients with T1D IAH.Research design and methods 54 patients were included into the study (18 T1D IAH, 18 T1D with normal awareness of hypoglycemia (NAH) and 18 healthy controls). We measured plasma NfL levels and studied cerebral gray matter alterations on MRI.Results We found that NfL levels were increased in patients with T1D IAH compared with patients with T1D NAH and healthy controls. Importantly, increased NfL levels correlated with reduced cerebral gray matter volume and increased IAH severity in patients with T1D IAH.SH is associated with adverse clinical consequences and cerebral damage.There is no validated biomarker for this subgroup of patients.What are the new findings?Plasma neurofilament light chain (NfL) levels were increased in patients with T1D IAH compared to patients with T1D with normal awareness of hypoglycemia and healthy controls.Increased NfL levels correlated with reduced cerebral gray matter volume and increased IAH severity in patients with T1D IAH.How might these results change the focus of research or clinical practice?Plasma Nfl levels could be used as a non invasive, cost effective, and logistically efficient biomarker of neuroaxonal damage in patients with T1D IAH.IntroductionAbout one in five patients with type 1 diabetes (T1D) have impaired awareness of hypoglycemia (IAH).1 IAH represents a risk factor for severe and recurrent hypoglycemic events, which can lead to brain damage.2 3 As no effective treatment has been clearly established,4 biomarkers capable of detecting and quantifying cerebral damage in this population are needed for the design of novel preventive or therapeutic strategies.On the one hand, cerebral atrophy or functional impairment can be assessed using neuroimaging techniques. cheap nba Jerseys from china

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