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Other genes from the same family are Presenilin 1(on

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Certain genes are known to have an influence in Alzheimer’s disease. The first is Amyloid precursor protein (on the twenty first chromosome) which is a regulator of synapse formation, neural plasticity, iron export, and is a precursor for beta amyloid. Other genes from the same family are Presenilin 1(on the fourteenth chromosome) and Presenilin 2 (on chromosome 1) which undergo a cleavage so that a larger N terminal and smaller C terminal are produced.

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